1.Date of occurrence of the event:2022/02/08

2.Company name:Microbio Co.,LTD.

3.Relationship to the Company (please enter ”head office” or

”subsidiaries”):Head office

4.Reciprocal shareholding ratios:NA

5.Cause of occurrence:The Company has been informed by the patent agency that

the new drug MS-20 has been granted a U.S. patent titled ”METHOD OF

ACTIVATING TUMOR-INFILTRATING LYMPHOCYTES (TILS)” under patent number

US 11,179,425 B2.

6.Countermeasures:NA

7.Any other matters that need to be specified:

The patents from the U.S., the Republic of China, Japan, the People’s

Republic of China, the Hong Kong Special Administrative Region, Europe, Korea,

Indonesia, India, Canada, Singapore, Malaysia and United Arab Emirates have

been subsequently granted on the new drug, Chemoyoung (MS-20).

This patent presents a combination therapy with Chemoyoung (MS-20) and

anti-PD1 antibody in colon cancers where the tumor-infiltrating lymphocytes

(TILs) were increased and migrated into the cancer cells. This transformed

a cold tumor to a hot tumor and improved the effect of immunotherapy, leading

to the significant reduction of the tumor volume.