1.Date of occurrence of the event:2021/12/16

2.Company name:

Microbio (Shanghai) Co., Ltd. (Referred to as Microbio (Shanghai))

3.Relationship to the Company (please enter ”head office” or

   ”subsidiaries”):subsidiaries

4.Reciprocal shareholding ratios:NA

5.Cause of occurrence:

   The Company has been informed by Oneness Biotech Co., LTD. that Macau issued

   ”Prior Authorisation for Import of Traditional Medicines” on Fespixon cream

   (Research code: ON101).

6.Countermeasures:None

7.Any other matters that need to be specified:

(1) The exclusive commercialization right of Fespixon cream

     (Research code: ON101), a new drug for diabetic foot ulcer,

     for mainland China, Hong Kong and Macau has been licensed to

     Microbio (Shanghai) in 2018.

(2) Fespixon cream can be exported to Macau after receiving

     ”Prior Authorisation for Import of Traditional Medicines” from

     Macau Health Bureau.